Aiming at the management requirement of real-time personnel statistics in office scenes with relatively fixed personnel positions, a laboratory personnel statistics and management system based on Faster Region-based Convolutional Neural Network (Faster R-CNN) and Intersection over Union (IoU) optimization was designed and implemented with an ordinary university laboratory as the example. Firstly, Faster R-CNN model was used to detect the heads of the people in the laboratory. Then, according to the output results of the model detection, the repeatedly detected targets were filtered by using IoU algorithm. Finally, a coordinate-based method was used to determine whether there were people at each workbench in the laboratory and store the corresponding data in the database. The main functions of the system are as follows:① real-time video surveillance and remote management of the laboratory; ② timed automatic photo, detection and acquisition of data to provide data support for the quantitative management of the laboratory; ③ laboratory personnel change data query and visualization. The experimental results show that the proposed laboratory personnel statistics and management system based on Faster R-CNN and IoU optimization can be used for real-time personnel statistics and remote management in office scenes.